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Advance Analytical
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Pre-Clinical Screening and In Vitro Diagnostics Research (IVDr) - (for research use only)
High Throughput NMR for Development and Validation of High-Quality and Cost-Effective IVD-by-NMR research and pre-clinical in vitro Screening Assays.
Standardized nuclear magnetic resonance (NMR) spectroscopy platform enabling cost-effective, high-performance NMR pre-clinical screening and IVD-by-NMR discovery and validation (on RUO Level) of novel NMR assays. The new AVANCE IVDr system, presently for research use only, is a complete, proven and standardized platform for NMR pre-clinical research and screening, as well as for IVD-by-NMR research.
It features high sensitivity and information-rich output at 600 MHz proton-NMR frequency, and incorporates advanced hardware, software, automation, spectral libraries and standard operating procedures (SOPs) for high-performance biofluid assay validation and pre-clinical screening. Customer benefits include higher information content and spectral feature differentiation compared to low-field NMR systems, as well as excellent reproducibility, high throughput and potentially dramatically lower cost per sample for better preparation and support of clinical screening and IVD-by-NMR discovery and validation (on RUO level).
“The latest generation of Bruker NMR instruments gives us staggering day to day and long term reproducibility and reliability of spectral acquisition, coupled with the ability to do automated digital quantification of multiple metabolites. Thus, uniquely, the NMR technology platform can be used in simultaneous exploratory and targeted modes. We are totally committed to the use of NMR spectroscopy (in association with mass spectrometry) as a definitive bio-screening tool, and the latest technology developments now allow the deployment of the platform on an industrial scale.”
Professor Jeremy Nicholson, Director of the MRC-NIHR Phenome Centre and Head of the Department of Surgery and Cancer at Imperial College London
Study on NMR based Lipoprotein Subclass Analysis
Bruker is involved in a project to establish lipoprotein subclass analysis based on 1H-Nuclear Magnetic Resonance (1HNMR) spectroscopy on blood plasma or serum samples.
Urine Based Newborn Screening Project applying High Resolution NMR-Spectroscopy
INFAI GmbH and Bruker BioSpin GmbH are leading a project to establish NMR-based Screening of Newborns in Turkey.
A Novel Approach for the Environmental Study of Organisms in their Natural State
This breakthrough technology enables NMR to evaluate an intact organism to gain tremendous insights and assess the function and environmental effects on the organism’s substructures.
